Clinical Pharmacokinetics
4 articles in this category.
Trough vs. AUC Vancomycin Monitoring: What Changed
Vancomycin AUC monitoring replaced trough-only targets after 2020 ASHP/IDSA guidelines linked troughs >15 mg/L to rising nephrotoxicity rates.
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Vancomycin Dosing in Renal Impairment: A Guide
Vancomycin renal dosing requires matching dose intervals to CrCl, learn the four thresholds, dialysis adjustments, and when to call pharmacy.
Why Vancomycin Needs a Loading Dose
A vancomycin loading dose of 25–30 mg/kg achieves therapeutic concentrations immediately, without waiting 3–4 maintenance doses to reach steady state.
Cockcroft-Gault vs CKD-EPI for Vancomycin Dosing
The Cockcroft-Gault equation remains the standard for vancomycin dosing, not CKD-EPI, because it was used in the original vancomycin PK studies.