About Vancomycin Calculator
A free vancomycin dosing calculator built on evidence-based pharmacokinetic guidelines for clinical pharmacists, physicians, and pharmacy students.
Why We Built This
Vancomycin is one of the most common antibiotics used in hospitals, and also one of the most difficult to dose correctly. It has a narrow therapeutic index, significant inter-patient pharmacokinetic variability, and the consequences of under- or over-dosing are serious: therapeutic failure in one direction, nephrotoxicity in the other.
The 2020 joint guidelines from the American Society of Health-System Pharmacists (ASHP), Infectious Diseases Society of America (IDSA), and Pediatric Infectious Diseases Society (PIDS) changed the standard of care by shifting from trough-only monitoring to AUC-based dosing. We built this calculator to make those guidelines accessible to every clinician, not just those with access to expensive Bayesian dosing software.
This tool calculates loading dose, maintenance dose, dosing interval, estimated AUC₂₄, elimination half-life, and estimated trough from six patient inputs, using the same pharmacokinetic equations described in Rybak MJ et al. Pharmacotherapy 2020;40(13):1280–1315.
Evidence-Based Calculations
Every formula used in this calculator comes directly from the 2020 ASHP/IDSA/PIDS consensus guidelines. We cite the exact source (Rybak MJ et al., Pharmacotherapy 2020) on the calculator page.
Editorial Process
Calculator outputs are reviewed against reference pharmacokinetic textbooks and verified with multiple patient scenarios. Content is updated whenever guidelines change.
For Education, Not Clinical Orders
This tool provides initial dosing estimates only. It does not replace clinical judgment, therapeutic drug monitoring, or your institution's pharmacokinetics service. Always verify with a clinical pharmacist.
Who Maintains This Site
Vancomycin Calculator is maintained by a team with a background in clinical pharmacokinetics and health informatics. We've worked alongside clinical pharmacy teams in hospital settings and understand how vancomycin dosing works in practice, not just in theory.
This is not a commercial product. There are no subscription fees, no paywall, and no account required. If you find an error in our calculations or content, please email us immediately. Accuracy is the entire point.
Contact Us
Found a calculation error? Have a clinical question about vancomycin dosing? Want to suggest an improvement?
contact@vancomycincalculator.com